The refractive index (or index of refraction) of a medium is a measure for how much the speed of light (or other waves such as sound waves) is reduced inside the medium. This is a very important property of a material or compound, that may characterize a purity or composition of a mixture. Refractive index of a drug is a very important property of a drug product or API to know for the pharmaceutical industry because in many cases the size of drug particles are regulated. Existing laser particle size counters may actually estimate particle size if known the refractive index of the particle material. Normally the refractive index of a liquid or a gas is easy to measure using a suitable refractometer. However the refractive index of a fine powdered solid material is relatively difficult to measure. Have been developed techniques allowing measurement of the refractive index of solid materials, but most of them require a sample of material be manufactured in required shape. Most solid organic compounds such as drugs may not be made as a uniform transparent blocks. We use so called Becke line microscopic method to determine refractive index of powdered material. Wery often the material is soluble in the measurement media, so we have developed differential dynamic method and instrumentation for measurement of a refractive index of any powdered materials. 
or Fill an on-line test request form >>> |
